MagSi R&D Tools

MagSi Tools for Research and Development

MagSi RnD Tools


MagSi-Tools are surface activated magnetic beads for immobilization of proteins, peptides, nucleic acids or other molecules of interest. Different surface modifications allow for choosing the optimal product for the molecule to be coupled, and for the intended application.

MagSi-Direct enables coupling of the biological molecule of your choice, of a wide variety of medium-large molecules.

Couple the biological molecule of your choice



MagSi-Direct includes easy-to-use MagSi beads and coating solutions enabling the immobilization of your specific biological molecule to a magnetic support. With MagSi-Direct you can turn ANY molecule that interacts with a specific partner into a powerful new biomagnetic reagent. Just magnetize your molecule to unleash the power of magnetic bead technology in your research or project.

The coating of MagSi-Direct acts as a nanoglue, using non-specific electron donation from electron-rich groups of the target biomolecule including -COOH, -CONH-, -NH2, -NHR-, -NR2, -OH, -SH, -X. As a result, MagSi-Direct allows coupling of a wide variety of medium-large biological molecules, ranging from proteins such as antibodies, cell receptor proteins, lectins, peptide aptamers and enzymes to non-protein molecules.


MagSi-Direct product features:

  • •Paramagnetic beads and surface coating reagents for custom functionalization
  • •Efficient and delicate coupling for many sensitive targets
  • •Binding only takes a few minutes
  • •Produces non-covalent binding that is strong even under extreme conditions
  • •Maximum binding interaction with large biomolecules
  • •Functionalized beads can be stored ready-to-use in various aqueous buffers


MagSi-Direct can be used in many applications


  • •Capture or purify any analyte using magnetic beads
  • •Develop quantative magnetic affinity assay

Cell therapy research

  • •Use your own cell specific ligands to isolate cells of interest
  • •Isolate or concentrate minority cell populations gently and efficiently

Flow cytometry

  • •Remove interfering cell populations prior to flow analysis
  • •Attach your cell-specific ligand to MagSi-Direct beads and use it to pull out the interfering cells with a magnet
  • •Enhance FACS capabilities – add magnetic cell depletion or concentration steps before or after running a sort

Protein Chemistry

  • •Purify delicate proteins or complexes with ease
  • •Avoid complex chromatographic separations

MagSi-Direct 1.0

With a mean diameter of 1.0 μm, MagSi-Direct 1.0 is especially suitable for immunoassays and capture reactions in volumes ≤ 1000 μL. Includes ready-to-use MagSi-Direct 1.0 beads, 10X Immobilization Buffer and Blocking Buffer.

Art. No. Product Size
MD01029 MagSi-Direct 1.0 Small (contains 2 ml beads)
MD03029 MagSi-Direct 1.0 Medium (contains 10 ml beads)
MD04029 MagSi-Direct 1.0 Large (contains 100 ml beads)


MagSi-Direct 3.0

With a mean diameter of 3.0 μm, MagSi-Direct 3.0 is especially suitable for cell capture applications and capture reactions in high volumes or viscous samples. Includes ready-to-use MagSi-Direct 3.0 beads, 10X Immobilization Buffer and Blocking Buffer.

Art. No. Product Size
MD41029 MagSi-Direct 3.0 Small (contains 2 ml beads)
MD43029 MagSi-Direct 3.0 Medium (contains 10 ml beads)
MD44029 MagSi-Direct 3.0 Large (contains 100 ml beads)